Des(1-3)IGF-1 - truncated brain/gut form of IGF-1 lacking first 3 N-terminal residues. 10x higher potency than native IGF-1; low IGFBP affinity. Key compound for local IGF-1 receptor research.
Des(1-3)IGF-1 (IGF-DES) is a naturally occurring truncated form of IGF-1 produced by N-terminal proteolysis, resulting in deletion of the first three residues (Gly-Pro-Glu). This truncation significantly reduces binding to IGF binding proteins while increasing receptor binding potency approximately 10-fold compared to native IGF-1. Des-IGF-1 is found in human brain and intestinal tissue.
HPLC >=99%; LC-MS confirmed; endotoxin tested. Full CoA provided.
For Research Use Only. Not for human or veterinary use.
| Product Name | IGF-DES |
| CAS Number | 67763-96-6 |
| Purity | ≥99% (by HPLC) |
| Molecular Weight | 6,859.69 g/mol |
| Molecular Formula | C319H501N91O96S7 |
| Appearance | Sterile lyophilized powder |
| Storage | Store at -20C desiccated. Reconstituted in 10 mM HCl; use within 7 days at 2-8C. |
| Available Sizes | 1mg · Custom |
Store at -20C desiccated. Reconstituted in 10 mM HCl; use within 7 days at 2-8C.
24 months from manufacture when stored properly.
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IGF-DES · CAS 67763-96-6
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