Chimeric 32-mer containing the MDM-2-binding domain of p53 fused to a membrane-translocating signal. Selective in vitro cytotoxicity toward transformed cells. Key p53-HDM2 interaction research tool.
PNC-27 is a 32-amino acid chimeric peptide incorporating the MDM-2 (HDM-2)-binding domain of p53 (residues 12-26: PPLSQETFSDLWKLL) fused to a membrane-translocating sequence. In transformed cell models, PNC-27 selectively induces pore formation in the plasma membrane of cancer cells that aberrantly express HDM-2 at the cell surface. Non-transformed cells lacking surface HDM-2 are unaffected.
HPLC >=99%; LC-MS confirmed; endotoxin tested. Full CoA provided.
For Research Use Only. Not for human or veterinary use.
| Product Name | PNC-27 |
| CAS Number | 390348-44-4 |
| Purity | ≥99% (by HPLC) |
| Molecular Weight | 2,933.52 g/mol |
| Molecular Formula | C134H225N39O40S |
| Appearance | White lyophilized powder |
| Storage | Store at -20C desiccated. Stable >=24 months. Reconstituted: use within 7 days at 2-8C. |
| Available Sizes | 10mg · Custom |
Store at -20C desiccated. Stable >=24 months. Reconstituted: use within 7 days at 2-8C.
24 months from manufacture when stored properly.
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PNC-27 · CAS 390348-44-4
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